ULTRAVIOLET RADIATION INDUCED CHANGES IN MACROPHAGE ACTIVITY |
| |
| Authors: | Georgia B Schuller Kiki B Hellman † |
| |
| Institution: | U.S. Department of Health and Human Services. Public Health Service, Food and Drug Administration, Bureau of Radiological Health, Division of Biological Effects, 5600 Fishers Lane, Rockville, MD 20857, USA |
| |
| Abstract: | Abstract— The effect of ultraviolet (UV) radiation on macrophage activity was examined. Thioglycollate-stimulated peritoneal exudate cells were collected from adult C57BL/6 mice. Ninety-five per cent of the cells adhering to plastic petri dishes were macrophages as determined by the presence of a non-specific esterase. Adherent cells were exposed to UV radiation of 0.5-13.2 J/m2. Viability and phagocytosis were measured at 0, 24, 48, 72 and 96 h after exposure. A statistically significant UV exposure-dependent decrease in macrophage viability and phagocytic capacity was observed. Macrophage viability and phagocytosis also decreased as a function of time after exposure to UV radiation. |
| |
| Keywords: | |
|
|
