|
|||||
|
|
SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols |
|
| Authors: | Heinrich Berger Werner Seebacher Marcel Kaiser Reto Brun Robert Saf Robert Weis |
| Institution: | 1.Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry,University of Graz,Graz,Austria;2.Swiss Tropical Institute,Basel,Switzerland;3.Institute of Chemical Technology of Organic Materials,Erzherzog-Johann University,Graz,Austria |
| Abstract: | Abstract Several 4-amino-6,7-diarylbicyclo2.2.2]octan-2-ols bearing varying substituents on the aromatic rings were synthesized following
a manual method for applying the Hansch approach. All new compounds were tested for their activity against the causative organisms
of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed.
Graphical abstract
 |
| Keywords: | Amino alcohols Drug research East African sleeping sickness Malaria tropica Structure-activity relationships |
| 本文献已被 SpringerLink 等数据库收录！ | |