A general method for the enantioselective synthesis of pantolactone derivatives |
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| Authors: | Evans David A Wu Jimmy Masse Craig E MacMillan David W C |
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| Institution: | Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA. evans@chemistry.harvard.edu |
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| Abstract: | An efficient enantioselective synthesis of beta,beta-dialkyl-gamma-substituted pantolactones has been achieved utilizing the cationic Sc((S,S)-R-pybox)](Cl)(2)(+), R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in high enantiomeric excesses. reaction: see text] |
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