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Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease |
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| Authors: | Kogen Hiroshi Toda Narihiro Tago Keiko Marumoto Shinji Takami Kazuko Ori Mayuko Yamada Naho Koyama Kazuo Naruto Shunji Abe Kazumi Yamazaki Reina Hara Takao Aoyagi Atsushi Abe Yasuyuki Kaneko Tsugio |
| Institution: | Exploratory Chemistry Research Laboratories, Research Information Department, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. hkogen@shina.sankyo.co.jp |
| Abstract: | Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT. structure: see text] |
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