An efficient method for synthesis of succinate-based MMP inhibitors |
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| Authors: | Sibi Mukund P Hasegawa Hikaru |
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| Institution: | Department of Chemistry and Center for Protease Research, North Dakota State University, Fargo, ND 58105, USA. |
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| Abstract: | A differentially protected fumarate undergoes radical addition followed by allylstannane trapping to provide disubstituted succinates in good yields and high anti diastereoselectivity. The conversion of the succinate to a known MMP inhibitor has been accomplished. reaction: see text] |
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