Thermal
behavior of some N,N-dimethylbiguanide derivatives displaying antimicrobial
activity |
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Authors: | Rodica
Olar Mihaela Badea Veronica Lazar Carmen Balotescu Elena Cristurean Dana Marinescu |
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Institution: | (1) Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, Bucharest, Romania, 050663 Sector 5, 90-92 Panduri Str.;(2) Faculty of Biology, Department of Microbiology, University of Bucharest, Bucharest, Romania, 1-3 Aleea Portocalilor St. |
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Abstract: | N,N-Dimethylbiguanide derivatives (HDMBG)X, where X=CH3COO
(1), Cl (2)
and NO3 (3) respectively,
exhibit in vitro antimicrobial activity
on representative bacterial and fungal strains. The presence of N,N-dimethylbiguanidium
ion for all derivatives was evidenced by IR and 1H
NMR spectra. Thermal analysis gave information on their decomposition steps
and also on the accompanying thermodynamic effects. According to TG and DTG
curves processes as melting, oxidative degradation as well as oxidative condensation
of –C=N– units occur. The different nature of the anions results
different melting points. Paracyanide formation at various condensation degrees
was observed. |
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Keywords: | antimicrobial activity N N-dimethylbiguanide paracyanide thermal behaviour |
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