| Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin |
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| 作者姓名： | Qing Song ZHOU Xue Hua JIANG Jia Rui YU Ke Jia LI West China School of Pharmacy Sichuan University Chengdu |
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| 作者单位： | Qing Song ZHOU，Xue Hua JIANG，Jia Rui YU，Ke Jia LI West China School of Pharmacy，Sichuan University，Chengdu 610041 |
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| 摘 要： | Scutellarin is the active ingredient extracted from Erigeron breviscapus, a traditional Chinese herbal medicine. Pharmacological study showed that scutellarin could significantly reduce the blood viscosity, improve the blood flow, decrease the vascular re…
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Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin |
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| Qing Song ZHOU,Xue Hua JIANG,Jia Rui YU,Ke Jia LI West China School of Pharmacy,Sichuan University,Chengdu .Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J].Chinese Chemical Letters,2006,17(1). |
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| Authors: | Qing Song ZHOU Xue Hua JIANG Jia Rui YU Ke Jia LI |
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| Abstract: | Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scutellarin. |
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| Keywords: | Scutellarin PEGylation prodrug physicochemical properties stability |
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