Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei |
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| Authors: | Takada Kentaro Uehara Taisuke Nakao Yoichi Matsunaga Shigeki van Soest Rob W M Fusetani Nobuhiro |
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| Affiliation: | Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. |
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| Abstract: | Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C(28) fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit alpha-glucosidase with IC(50) values of 48-170 nM. |
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