| Total Synthesis of Tetrahydroquinoline Alkaloid （＋）-Angustureine |
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| 引用本文： | 林宪峰 李瑜 马大为. Total Synthesis of Tetrahydroquinoline Alkaloid （＋）-Angustureine[J]. 中国化学, 2004, 22(9): 932-934. DOI: 10.1002/cjoc.20040220911 |
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| 作者姓名： | 林宪峰 李瑜 马大为 |
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| 作者单位： | [1]DepartmentofChemistry,LanzhouUniversity,Lanzhou730000,China [2]StateKeyLaboratoryofBioorganicandNaturalProductsChemistry,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 基金项目： | the National Natural Science Foundation of China (Nos. 20321202,20132030). |
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| 摘 要： | ( )-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enantiopure β-amino ester as the key step. The overall yield is 36% in 7 linear steps.
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| 关 键 词： | 四氢喹啉 生物碱 合成 碘化铜 催化剂 碘代苯 β-氨基酯 |
Total Synthesis of Tetrahydroquinoline Alkaloid (+)-Angustureine |
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| LIN,Xian-Fenga,b LI,Yua MA,Da-Wei,b a. Total Synthesis of Tetrahydroquinoline Alkaloid (+)-Angustureine[J]. Chinese Journal of Chemistry, 2004, 22(9): 932-934. DOI: 10.1002/cjoc.20040220911 |
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| Authors: | LIN Xian-Fenga b LI Yua MA Da-Wei b a |
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| Affiliation: | LIN,Xian-Fenga,b LI,Yua MA,Da-Wei*,b a Department of Chemistry,Lanzhou University,Lanzhou 730000,China b State Key Laboratory of Bioorganic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | (+)-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enan-tiopure -amino ester as the key step. The overall yield is 36% in 7 linear steps. |
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| Keywords: | alkaloid total synthesis coupling |
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