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99mTc-radiolabeled imidazo[2,1-b]benzothiazole derivatives as potential radiotracers for glioblastoma |
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| Authors: | Nosrati Sahar Molavipordanjani Sajjad Emami Saeed Abedi Seyed Mohammad Talebpour Amiri Fereshteh Hosseinimehr Seyed Jalal |
| Institution: | 1.Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ;2.Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran ;3.Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran ;4.Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ;5.Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; |
| Abstract: | This study presents 99mTc]BPTG-1 and 99mTc]BPTG-2 for glioblastoma imaging. In vitro cellular uptakes of these radiotracers were examined in SKOV-3, MCF-7, U87-MG, HT-29, and A549 cell lines. U87-MG cell line displayed the highest radiotracers uptakes. Biodistribution study in U87-MG tumor bearing mice revealed higher uptake of radiotracers in tumor than muscle and brain. Liver, intestine, and kidneys displayed the highest radioactivity uptakes. The main route of radiotracers elimination was hepatobiliary. Due to the brain uptake of these radiotracers, they are promising radiotracers for future studies in the diagnosis of glioblastoma. |
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