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Ag2WO4 nanoparticles radiolabeled with technetium-99m: a potential new tool for tumor identification and uptake |
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| Authors: | Santos Carla Júnia Filho Francisco Moura Campos Fernanda Lapa Ferreira Carolina de Aguiar de Barros André Luís Branco Soares Daniel Crístian Ferreira |
| Affiliation: | 1.Laboratório de Bioengenharia, Universidade Federal de Itajubá, Rua Irmã Ivone Drumond, 200, Distrito Industrial II, Itabira, Minas Gerais, 35903-087, Brazil ;2.Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil ;3.Department of Biomedical Engineering, University of Wisconsin-Madison, Highland Avenue, 1111, Madison, WI, 53705, USA ; |
| Abstract: | Silver tungstate nanoparticles have been presenting attractive characteristics that could allow its usage in the biomedical sciences. In this study, Ag2WO4 nanoparticles with an average size of 242 nm were obtained and radiolabeled with technetium-99m with high labeling-yield as well as high stability. Biodistribution studies were carried out in healthy and tumor-bearing mice to determine the nanoparticle’s in vivo behavior. The results revealed an important tumor-to-muscle ratio, reaching values above than 1.5, demonstrated the ability of this nanomaterial in accumulating preferentially in tumor tissue. All results together, converge to consider the Ag2WO4 nanoparticles as a potential system against cancer and a potential new radiolabeled probe for tumor identification and uptake. |
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