| 奥美拉唑对映体在自制手性柱上吸附等温线的测定 |
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| 引用本文： | 陈明杰,沈波,危凤. 奥美拉唑对映体在自制手性柱上吸附等温线的测定[J]. 离子交换与吸附, 2007, 23(1): 71-76 |
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| 作者姓名： | 陈明杰 沈波 危凤 |
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| 作者单位： | 浙江大学宁波理工学院生物与制药工程系,宁波 315100;浙江大学宁波理工学院生物与制药工程系,宁波 315100;浙江大学宁波理工学院生物与制药工程系,宁波 315100 |
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| 基金项目： | 浙江省宁波市科技攻关计划 |
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| 摘 要： | 采用吸附-脱附法研究了奥美拉唑对映体在自制的纤维素三苯基氨基甲酸酯涂敷型手性柱上的吸附性能,并用Langmuir方程拟合出吸附平衡方程.当样品浓度降低时,Langmuir方程退化为直线关系,直线斜率即为吸附平衡常数.这一吸附平衡常数与从脉冲色谱流出曲线求得的吸附平衡常数相等,表明吸附-脱附法测得的吸附平衡关系准确,Langmuir方程能描述这一吸附平衡关系.
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| 关 键 词： | 奥美拉唑 吸附-脱附法 吸附等温线 对映体 手性柱 |
| 文章编号： | 1001-5493(2007)01-0071-06 |
| 修稿时间： | 2006-07-21 |
ADSORPTION ISOTHERM DETERMINATION OF OMEPRAZOLE ENANTIOMERS ON SELF-MADE CHIRAL COLUMN |
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| CHEN Mingjie,SHEN Bo,WEI Feng. ADSORPTION ISOTHERM DETERMINATION OF OMEPRAZOLE ENANTIOMERS ON SELF-MADE CHIRAL COLUMN[J]. Ion Exchange and Adsorption, 2007, 23(1): 71-76 |
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| Authors: | CHEN Mingjie SHEN Bo WEI Feng |
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| Affiliation: | Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China |
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| Abstract: | Adsorption isotherm of enantiomers of omeprazole on the coated triphenycarbamate cellulose chiral stationary phases were determined by adsorption-desorption method. In order to reduce the amount of sample, a short chromatographic column was used. The experimental data were fitted with the equation of Langmuir well. When the concentration of sample decreases, Langmuir equation was degraded to be a linear equation. The slope of the line is adsorption equilibrium constants, which is equal to the value derived form the elution curve of a pulse chromatography. This shows that adsorption isotherms can be measured by the adsorption-desorption method very accurately and Langmuir equation can describe the adsorption equilibrium relation well. |
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| Keywords: | Omeprazole Adsorption-desorption method Adsorption isotherm Enantiomer Chiral column. |
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