Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica |
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Authors: | Buchanan Greg O Williams Philip G Feling Robert H Kauffman Christopher A Jensen Paul R Fenical William |
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Institution: | Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA. |
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Abstract: | structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography. |
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