Rhodium- and iridium-catalyzed oxidative coupling of benzoic acids with alkynes via regioselective C-H bond cleavage |
| |
Authors: | Ueura Kenji Satoh Tetsuya Miura Masahiro |
| |
Institution: | Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. |
| |
Abstract: | The oxidative coupling of benzoic acids with internal alkynes effectively proceeds in the presence of Cp*RhCl2]2 and Cu(OAc)2 x H2O as catalyst and oxidant, respectively, to produce the corresponding isocoumarin derivatives. The copper salt can be reduced to a catalytic quantity under air. Interestingly, by using Cp*IrCl2]2 in place of Cp*RhCl2]2, the substrates undergo 1:2 coupling accompanied by decarboxylation to afford naphthalene derivatives exclusively. In this case, Ag2CO3 acts as an effective oxidant. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|