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测定核间距的不对称2D NOESY方法——1.从不对称2D NOESY峰强度求取完整的混合系数矩阵
引用本文:缪希茄,韩秀文,胡皆汉. 测定核间距的不对称2D NOESY方法——1.从不对称2D NOESY峰强度求取完整的混合系数矩阵[J]. 波谱学杂志, 1993, 0(3)
作者姓名:缪希茄  韩秀文  胡皆汉
作者单位:中国科学院大连化学物理研究所,中国科学院大连化学物理研究所,中国科学院大连化学物理研究所 大连 116023 中国科学院武汉物理研究所波谱与原子分子物理国家重点实验室,武汉 430071,大连 116023,大连 116023
摘    要:本文提出不对称2D NOESY实验方法来测定完整的2D NOESY混合系数矩阵。理论研究表明,不对称2D NOESY实验信澡比要比传统2D NOESY的高,不对称2D NOESY峰强度矩阵是非对称的,因此可以只用不对称2D NOESY的非对角峰强度来求得完整的2D NOESY混合系数矩阵,避免测量大分子等复杂自旋系统的严重重叠的对角峰强度所引起的困难,而这是传统2D NOESY实验方法所无法作到的。本文最后应用数值模拟方法对理论研究结果进行了计算验证。

关 键 词:不对称2D NOESY  混合系数矩阵  核交叉弛豫速率  核间距

DETERMINATION OF INTERNUCLEAR DISTANCES FROM THE NONSYMMETRIC 2D NOESY METHOD
. Measurement for the full matrix of D NOESY mixing coefficient by the nonsymmetric D NOESYMiao Xijia,Han Xiuwen and Hu Jiehan. DETERMINATION OF INTERNUCLEAR DISTANCES FROM THE NONSYMMETRIC 2D NOESY METHOD[J]. Chinese Journal of Magnetic Resonance, 1993, 0(3)
Authors:. Measurement for the full matrix of D NOESY mixing coefficient by the nonsymmetric D NOESYMiao Xijia  Han Xiuwen  Hu Jiehan
Affiliation:1. Measurement for the full matrix of 2D NOESY mixing coefficient by the nonsymmetric 2D NOESYMiao Xijia,Han Xiuwen and Hu Jiehan
Abstract:The nonsymmetric 2D NOESY method is proposed to measure the full 2D NOESY mixing coefficient matrix. Theoretical researchs showed that the nonsymmetric 2D NOESY has a nonsymmetric peak intensity matrix and a higher signal-to-noise ratio than the conventional one. Therefore, it is possible that the full 2D NOESY mixing coefficient matrix can be obtained only from the off-diagonal elements of peak intensity matrix of the nonsymmetric 2D NOESY, which is impossible for the conventional 2D NOESY, and the peak intensity measurement of overlapping diagonal elements of the nonsymmetric 2D NOESY in such spin systems as biomacromolecules may be avoided doing. In the final the theoretical results were confirmed with numerical simulated studies.
Keywords:Nonsymmetric 2D NOESY  2D NOESY mixing coefficient matrix  Nuclear cross-relaxation rate  Internuclear distance .  
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