Nanocomposites of gold nanoparticles with pregabalin: The future anti-seizure drug |
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| Institution: | 1. Physics Department, College of Applied Sciences, Umm Al-Qura University (UQU), Makkah, Saudi Arabia;2. Department of Forensic Sciences, Forensic Toxicology, College of Criminal Justice, Naif Arab University for Security Sciences, P.O. Box: 60405, Riyadh 11545, Saudi Arabia;3. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
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| Abstract: | Application of nanoparticles in drug delivery has become an emerging phenomenon. This is typically achieved either via custom made nanoparticles or through the functionalization of pre-synthesized nanoparticles with the pharmaceutically active ingredients. In this study, Pregabalin, which is the active pharmaceutical ingredient of commercially available drug Lyrica, is used to functionalize pre-synthesized gold nanoparticles (AuNPs). The work was divided into two parts. The first part determined by synthesis of AuNPs. The second part was achieving conjugation of the AuNPs with Pregabalin to obtain nanocomposites (AuNPs-PGN). AuNPs formed were nanosized, spherical in shape, with a particle size ~35 nm. The probable nanocomposite formation takes place by conjugation between AuNPs and the carboxyl group (COOH) of Pregabalin. |
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| Keywords: | AuNPs Pregabalin Nanocomposites Drug delivery |
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