| 邻菲咯啉合铜配合物与牛血清白蛋白的相互作用 |
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| 引用本文： | 黄钰婷,任祥祥,刘海峰,乐学义.邻菲咯啉合铜配合物与牛血清白蛋白的相互作用[J].化学研究,2009,20(2):37-40. |
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| 作者姓名： | 黄钰婷 任祥祥 刘海峰 乐学义 |
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| 作者单位： | 华南农业大学理学院应用化学系,广东,广州,510642 |
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| 基金项目： | 广东省自然科学基金重点项目 |
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| 摘 要： | 利用荧光光谱法研究了两种配合物，Cu（phen）（L-Phe）（H2O）]ClO4（1）（L-Phe为L-苯丙氨酸根）和Cu（phen）（Gly）（H2O）]ClO4·2．5H2O（2）（Cly为甘氨酸根），与牛血清白蛋白（BSA）的相互作用。结果表明，牛血清白蛋白的荧光强度随着配合物浓度的增大而逐渐降低，配合物（2）与BSA的结合常数大于配合物（1）与BSA的结合常数，牛血清白蛋白对配合物的结合位点数为1，荧光猝灭作用机理为静态猝灭．
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| 关 键 词： | Cu(Ⅱ)配合物 1 10-邻菲咯啉 氨基酸 牛血清白蛋白 荧光光谱 |
Interaction Between 1,10-Phenanthroline Aminoacidato Copper(II) Complexes and Bovine Serum Albumin |
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| HUANG Yu-ting,REN Xiang-xiang,LIU Hai-feng,LE Xue-yi.Interaction Between 1,10-Phenanthroline Aminoacidato Copper(II) Complexes and Bovine Serum Albumin[J].Chemical Research,2009,20(2):37-40. |
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| Authors: | HUANG Yu-ting REN Xiang-xiang LIU Hai-feng LE Xue-yi |
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| Institution: | ( Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642, Guangdong, China) |
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| Abstract: | The binding interaction between the complexes,ClO4(1)(L-Phe=L-phenylalanine, ClO4·2.5H2O(2)(Gly =glycine) and bovine serum albumin(BSA) was investigated by fluorescence spectroscopy technique.The results showed that the fluorescence strength of BSA decreased with the increase of the complex concentration,and the binding constant K for complex(2) is bigger than that for complex(1),and the binding site number of BSA to the complexes is 1. |
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| Keywords: | copper(Ⅱ)complex 1 10-phenanthroline amino acid bovine serum albumin fluorescence spectroscopy |
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