苯环2-位不同酯基取代的磺酰脲类化合物的合成及其除草活性

以正在开发的磺酰脲类超高效除草剂NK94827[N'-(4'-甲基嘧啶-2'-基)-2-甲氧羰基苯磺酰脲]的基本结构为基础,设计合成了18个苯环2位不同酯基取代的的新型磺酰脲类化合物,产物结构均经¹HNMR及元素分析确证.经油菜平皿法和盆栽试验测试除草活性,所合成的部分磺酰脲化合物的除草活性高.

Synthesis and Herbicidal Activity of New Sulfonylurea Derivatives

In order to search for more environmental-benign sulfonylurea herbicides and study their structure-activity relationship, on the basis of a new sulfonylurea herbicide NK94827 {N-[(4'-methyl)pyrimidin-2'-yl]-2-methoxycarbonyl phenylsulfonylurea}, 18 novel sulfonylurea compounds modified at benzoic acid ester were synthesized. The structures of the target compounds were confirmed by 1HNMR and elemental analysis. Preliminary herbicidal activity of these new sulfonylurea compounds was determined by rape disc assay and pot bioassay experiments. The results indicate that some compounds have good a herbicidal activity, and large lipophilic groups in ester moiety are unfavorable for the activity.