Reaction of ethyl 4-[(E)-1-chloro-3-oxoprop-1-en-1-yl]-3,5-dimethyl-1H-pyrrole-2-carboxylate with hydrazines |
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| Authors: | E. I. Mikhed’kina O. S. Bylina I. I. Mel’nik D. T. Kozhich |
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| Affiliation: | (1) “Kharkov Polytechnical Institute” National Technical University, ul. Frunze 21, Kharkov, 61002, Ukraine;(2) Medical Biology Institute, Minsk, Belarus |
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| Abstract: | Ethyl 4-[(E)-1-chloro-3-oxoprop-1-en-1-yl]-3,5-dimethyl-1H-pyrrole-2-carboxylate reacted with substituted hydrazines in different solvents to give mixtures of regioisomeric 3- and 5-substituted pyrazoles. Conditions were found for selective formation of 1-aryl(alkyl)-5-(5-ethoxycarbonyl-2,4-dimethyl-1H-pyrrol-3-yl)-1H-pyrazoles. |
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