Total synthesis of the cyanolide A aglycon |
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Authors: | Gesinski Michael R Rychnovsky Scott D |
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Institution: | Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA. |
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Abstract: | The synthesis of the potent molluscicide cyanolide A has been achieved in 10 steps without the use of protecting groups. The synthesis features a key Sakurai macrocyclization/dimerization reaction that simultaneously forms both tetrahydropyran rings and the macrocycle of the natural product. |
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