Using electrophoretic exclusion to manipulate small molecules and particles on a microdevice |
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Authors: | Kenyon Stacy M Weiss Noah G Hayes Mark A |
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Institution: | Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. |
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Abstract: | Electrophoretic exclusion, a novel separations technique that differentiates species in bulk solution using the opposing forces of electrophoretic velocity and hydrodynamic flow, has been adapted to a microscale device. Proof-of-principle experiments indicate that the device was able to exclude small particles (1 μm polystyrene microspheres) and fluorescent dye molecules (rhodamine 123) from the entrance of a channel. Additionally, differentiation of the rhodamine 123 and polystyrene spheres was demonstrated. The current studies focus on the direct observation of the electrophoretic exclusion behavior on a microchip. |
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Keywords: | Capillary electrophoresis Electrophoretic exclusion Microscale Separations |
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