| 三种1,10-邻菲咯啉-铜(Ⅱ)-L-氨基酸配合物与DNA的相互作用 |
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| 引用本文： | 古 琴,乐学义,谢 韵,洪来法,庄楚雄.三种1,10-邻菲咯啉-铜(Ⅱ)-L-氨基酸配合物与DNA的相互作用[J].无机化学学报,2006,22(4):757-760. |
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| 作者姓名： | 古 琴 乐学义 谢 韵 洪来法 庄楚雄 |
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| 作者单位： | 1. 华南农业大学理学院应用化学系,广州,510642
2. 华南农业大学生命科学学院,广州,510642 |
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| 基金项目： | 国家自然科学基金;华南农业大学校科研和教改项目 |
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| 摘 要： | The Interaction of three complexes Cu(phen)(Gly)(H2O)]·ClO4·2.5H2O (1), Cu(phen)(L-Val)(H2O)]·ClO4 (2) and Cu(phen)(L-Ile)(H2O)]·ClO4 (3) (phen=1,10-phenanthroline, Gly=glycinate, L-Val=L-valinate, L-Ile=L-isoleucinate) with DNA have been investigated by electronic absorption spectroscopy, ethidium bromide(EB) fluorescence spectroscopy, viscosity and gel electrophoresis measurements. The intensity of maximal absorption peaks from absorption spectra are weakened with dropping DNA into the complexes. The emission intensity of EB-DNA systems in fluorescence spectroscopy have descended 50%, when the data of CCu / CDNA is 30～40. Moreover, the viscosity of DNA increase and then decrease with the increasing of complexes. All of the results indicate that the interaction of complexes with DNA are partial intercalation, and the result of agarose gel electrophoresis show that the complexes can cleave pBR322 DNA in the present of H2O2 / vitamin C.
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| 关 键 词： | 铜(Ⅱ)三元配合物 1，10-邻菲咯啉 L-氨基酸 DNA |
| 文章编号： | 1001-4861(2006)04-0757-04 |
| 收稿时间： | 2005-10-17 |
| 修稿时间： | 2006-01-16 |
Interaction of Three 1,10-Phenanthroline-Copper(Ⅱ)-L-Amino Acid Complexes with DNA |
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| GU Qin,LE Xue-Yi,XIE Yun,HONG Lai-Fa and ZHUANG Chu-Xiong.Interaction of Three 1,10-Phenanthroline-Copper(Ⅱ)-L-Amino Acid Complexes with DNA[J].Chinese Journal of Inorganic Chemistry,2006,22(4):757-760. |
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| Authors: | GU Qin LE Xue-Yi XIE Yun HONG Lai-Fa and ZHUANG Chu-Xiong |
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| Institution: | Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642,Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642,Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642,College of Life Science, South China Agricultural University, Guangzhou 510642 and College of Life Science, South China Agricultural University, Guangzhou 510642 |
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| Abstract: | |
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| Keywords: | DNA |
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