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Stereoselective Electro‐2‐deoxyglycosylation from Glycals |
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| Authors: | Miao Liu Kai‐Meng Liu De‐Cai Xiong Hanyu Zhang Tian Li Bohan Li Xianjin Qin Jinhe Bai Xin‐Shan Ye |
| Abstract: | We report a novel and highly stereoselective electro‐2‐deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional‐group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one‐pot trisaccharide synthesis through iterative electroglycosylations were achieved. |
| Keywords: | 2-deoxyglycosides carbohydrates electrocatalysis glycals glycosylation |