Qk is the simple graph whose vertices are the k‐tuples with entries in {0, 1} and edges are the pairs of k‐tuples that differ in exactly one position. In this paper, we proved that there exists a Q5‐factorization of λKn if and only if (a) n ≡ 0(mod 32) if λ ≡ 0(mod 5) and (b) n ≡ 96(mod 160) if λ ? 0(mod 5).