A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells |
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| Authors: | Jing‐Jing Zhang,Mohamed A. Abu el Maaty,Henrik Hoffmeister,Claudia Schmidt,Julienne K. Muenzner,Rainer Schobert,Stefan W lfl,Ingo Ott |
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| Affiliation: | Jing‐Jing Zhang,Mohamed A. Abu el Maaty,Henrik Hoffmeister,Claudia Schmidt,Julienne K. Muenzner,Rainer Schobert,Stefan Wölfl,Ingo Ott |
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| Abstract: | A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1‐yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti‐metastatic, and anti‐angiogenic effects. The complex also induced effects related to aneuploidy in HCT‐116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs. |
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| Keywords: | aneuploidy antitumor agents gold complexes inorganic medicinal chemistry metallodrugs |
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