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Asymmetric Dearomative Fluorination of 2‐Naphthols with a Dicarboxylate Phase‐Transfer Catalyst
Authors:Hiromichi Egami  Taiki Rouno  Tomoki Niwa  Kousuke Masuda  Kenji Yamashita  Yoshitaka Hamashima
Abstract:A linked dicarboxylate phase‐transfer catalyst enables smooth asymmetric dearomative fluorination of 2‐naphthols with Selectfluor under mild conditions to give the corresponding 1‐fluoronaphthalenone derivatives in a highly enantioselective manner. This reaction, which is compatible with a range of functional groups, is the first example of catalytic asymmetric fluorination of 2‐naphthols, and is expected to be useful in the synthesis of bioactive molecules.
Keywords:asymmetric catalysis  dearomatization  fluorination  naphthols  phase-transfer catalysis
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