Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging |
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| Authors: | Klra &#x;
upkov Frdric Dewez Axel K Walch Ron M A Heeren Benjamin Balluff |
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| Institution: | Klára Ščupáková,Frédéric Dewez,Axel K. Walch,Ron M. A. Heeren,Benjamin Balluff |
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| Abstract: | The large‐scale and label‐free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single‐cell‐specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features. |
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| Keywords: | imaging lipids mass spectrometry morphometry single-cell analysis |
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