Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids |
| |
Authors: | Johanna Claus Thomas Eickner Niels Grabow Udo Kragl Stefan Oschatz |
| |
Abstract: | In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3‐sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly‐[2‐(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion‐controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated. |
| |
Keywords: | drug delivery hydrogel ion exchange controlled release polymerized ionic liquids sterilization |
|