| Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals |
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| 作者姓名： | Suchen Zou Tianze Zhang Siyuan Wang Hanmin Huang |
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| 作者单位： | Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry;State Key Laboratory of Applied Organic Chemistry |
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| 基金项目： | This research was supported by the National Natural Science Foundation of China(Nos.21925111,21672199,21790333,and 21702197);the Fundamental Resedrch Funds for the Central Universities(No.WK2060190086). |
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| 摘 要： | Summary of main observation and conclusion A new and eficient cyclization reaction has bleen developed to synthesize cyclic a,a-disubstituted B-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction condi-tions.A broad range of hydroxy-a diazoesters with different substituents and various N,O-aminals were compatible with this protocol,affording the corresponding a,a-disubstitutedβ-amino esters bearing a five-to eight-membered oxacycle in good yields.
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| 关 键 词： | ESTERS SUBSTITUTED CYCLIZATION |
Iron‐Catalyzed Aminomethyloxygenative Cyclization of Hydroxy‐α‐diazoesters with N,O‐Aminals |
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| Suchen Zou,Tianze Zhang,Siyuan Wang,Hanmin Huang.Iron‐Catalyzed Aminomethyloxygenative Cyclization of Hydroxy‐α‐diazoesters with N,O‐Aminals[J].Chinese Journal of Chemistry,2020,38(4):389-393. |
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| Authors: | Suchen Zou Tianze Zhang Siyuan Wang Hanmin Huang |
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| Abstract: | A new and efficient cyclization reaction has been developed to synthesize cyclic α,α‐disubstituted β‐amino esters via iron‐catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O‐aminal under mild reaction conditions. A broad range of hydroxy‐α‐diazoesters with different substituents and various N,O‐aminals were compatible with this protocol, affording the corresponding α,α‐disubstituted β‐amino esters bearing a five‐ to eight‐membered oxacycle in good yields. |
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| Keywords: | Aminomethyloxygenative cyclization Diazoesters β – Amino acids N O– Aminals Iron |
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