Abstract: | Pillarn]arene, a new class of macrocycle was first introduced in the year 2008. Since then, it has gained much attention in supramolecular chemistry. The structural simplicity combined with its straightforward synthesis through one‐step reaction process paves the way to develop various functionalized materials. The electron‐rich cavities of pillarn]arene attached to suitable functional groups have been extensively used for various applications. This report will be focused on the challenges to engineer pillarn]arene scaffold to get functionalized materials, potential applications and their future scope.![image](/cms/asset/c3d55f4f-9adb-42eb-8b1c-a72e9a2b55a1/cjoc201900408-gra-0001.png) |