Synthesis and Penicillin‐binding Protein Inhibitory Assessment of Dipeptidic 4‐Phenyl‐β‐lactams from α‐Amino Acid‐derived Imines |
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| Authors: | Lena Decuyper Marko Juki
Izidor Sosi
Ana Maria Amoroso Olivier Verlaine Bernard Joris Stanislav Gobec Matthias D'hooghe |
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| Institution: | Lena Decuyper,Marko Jukič,Izidor Sosič,Ana Maria Amoroso,Olivier Verlaine,Bernard Joris,Stanislav Gobec,Matthias D'hooghe |
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| Abstract: | Monocyclic β‐lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six‐step synthetic route was developed, providing easy access to new 3‐amino‐1‐carboxymethyl‐4‐phenyl‐β‐lactams, of which the penicillin‐binding protein (PBP) inhibitory potency was demonstrated biochemically. |
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| Keywords: | amino acids antibiotics biological activity Staudinger synthesis β -lactams |
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