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Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors |
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| Authors: | Marco Colella Arianna Tota Yusuke Takahashi Ryosuke Higuma Susumu Ishikawa Leonardo Degennaro Renzo Luisi Aiichiro Nagaki |
| Abstract: | The external quenching method based on flow microreactors allows the generation and use of short‐lived fluoro‐substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics. |
| Keywords: | amides flow chemistry lithium microreactor reactive intermediates |