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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids |
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| Authors: | Gianluca Destro Kaisa Horkka Olivier Loreau David‐Alexandre Buisson Lee Kingston Antonio Del Vecchio Magnus Schou Charles S Elmore Frdric Taran Thibault Cantat Davide Audisio |
| Institution: | Gianluca Destro,Kaisa Horkka,Olivier Loreau,David‐Alexandre Buisson,Lee Kingston,Antonio Del Vecchio,Magnus Schou,Charles S. Elmore,Frédéric Taran,Thibault Cantat,Davide Audisio |
| Abstract: | A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes 14C] and 13C]. A proof of concept with 11C] was also obtained with low molar activity valuable for distribution studies. |
| Keywords: | carbon dioxide carbon-11 carbon-14 isotope exchange isotope labeling |