Synthesis of 5,6-dihydro-4H-thiopyran-4-ones |
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| Authors: | Jan Becher Klaus Brsndum Poul Hansen Jens Peter Jan Jacobsen |
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| Institution: | Jan Becher,Klaus Brøsndum,Poul Hansen,Jens Peter Jan Jacobsen |
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| Abstract: | The anions of 1,4-diaryl-3-buten-2-ones 1 reacts with arylisothiocyanates, yielding intermediates 4 which can ring close to 5,6-dihydro-4H-thiopyran-4-ones 5 . Under similar reaction conditions ethyl 3-oxo-4-pentenoates 7 gives the 6-spiropyrans 9 . Methylation of 3 gives the S-methylated open form 6 . |
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