Synthesis of 7,8,9,10-tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolines |
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| Authors: | Karl Sch nafinger,Christine M. Yasenchak,Anne Vollman,Helen H. Ong |
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| Affiliation: | Karl Schönafinger,Christine M. Yasenchak,Anne Vollman,Helen H. Ong |
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| Abstract: | A series of structurally novel 7,8,9,10-tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3-c,]quinolines, 4a-c , were synthesized via a facile Fischer indole cyclization from the appropriately substituted hydrazinoquinolines 2a-c . Acetamides 4a,c were hydrolyzed to 5a,b and further converted to tertiary amines 6a-c . Potent antihypertensive activity has been observed with a number of the title compounds as well as the intermediate 3a . |
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