| 硫代磷(膦)酰基脲类衍生物的合成及其生物活性 |
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| 引用本文： | 杨华铮,黄战鏖.硫代磷(膦)酰基脲类衍生物的合成及其生物活性[J].高等学校化学学报,1993,14(6):787-790. |
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| 作者姓名： | 杨华铮 黄战鏖 |
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| 作者单位： | 南开大学元素有机化学研究所, 天津 300071 |
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| 摘 要： | 通过O,O-二乙基硫代磷酰基异氰酸酯或O-乙基-苯基硫代膦酰基异氰酸酯与不同胺的加成反应,合成了一系列新型硫代磷(膦)酰基脲类化合物,其结构经元素分析、1HNMR及MS确证。初步的生物活性测定表明,这类化合物具有一定的除草、抗肿瘤及抑制几丁质形成活性。
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| 关 键 词： | 取代脲 硫代磷(膦)酰脲 生物活性 |
| 收稿时间： | 1992-07-29 |
Syntheses and Biological Activities of Thiophosphoryl (Thiophosphonyl) Urea Derivatives |
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| YANG Hua-Zheng,HUANG Zhan- Ao.Syntheses and Biological Activities of Thiophosphoryl (Thiophosphonyl) Urea Derivatives[J].Chemical Research In Chinese Universities,1993,14(6):787-790. |
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| Authors: | YANG Hua-Zheng HUANG Zhan- Ao |
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| Institution: | Department of Chemistry, Mm University, Changchun, 130023 |
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| Abstract: | The thiophosphoryl(thiophosphonyl) urea uerivatives, R(EtO)P(S)NHC(O)N (R1 )R2, (R =EtO, Ph: R1=alkyl, H; R2 = alkyl, aryl and heterocyclic radical) were synthesized by the addition reaction of R(EtO)P(S)NCO (R = EtO, Ph) to various amines respectively and their structures were confirmed by means of elemental analysis, 1H NMR and MS, Hie preliminary biological tests show that these compounds have herbicidal and anti-tumour activities and could inhibit the formation of chitin. |
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| Keywords: | Substituted ureas Thiophosphoryi(thiophosphonyi)ureas Biological activity |
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