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In vivo and in vitro testing of microelectronically fabricated planar sensors designed for applications in cardiology |
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| Authors: | Ernö Lindner Vasile V Cosofret Stefan Ufer Timothy A Johnson R Bruce Ash H Troy Nagle Michael R Neuman and Richard P Buck |
| Institution: | (1) Department of Chemistry, The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA;(2) School of Medicine, Division of Cardiology, The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA;(3) Department of Electrical and Computer Engineering, North Carolina State University, 27695 Raleigh, NC, USA;(4) Department of OB/GYN, Metro Health Medical Center, 44109 Cleveland, Ohio, USA;(5) Present address: Institute for General and Analytical Chemistry, Technical University of Budapest, Szent Gellért tér 4, H-1111 Budapest, Hungary |
| Abstract: | Summary Ion-sensitive, planar micro-electrode arrays were fabricated by photolithographic microelectronics technology on a flexible polyimide substrate. The steps of the microelectronics processing are summarized. The electrodes were tested in blood serum, whole blood and in the hamstring muscle of anesthetized rabbits. The performance characteristics of planar pH-sensors are compared with commercial glass electrodes. The close correlation of the data are encouraging for further acute and later chronic applications.Dedicated to Professor Dr. Wilhelm Fresenius |
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