Evidence for covalent binding of epicocconone with proteins from synchronous fluorescence spectra and fluorescence lifetimes |
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| Authors: | Debashis Panda and Anindya Datta |
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| Affiliation: | (1) Department of Chemistry, Indian Institute of Technology — Bombay, Powai, Mumbai, 400 076, India |
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| Abstract: | Synchronous fluorescence and time-resolved fluorescence spectroscopic studies that reveal the interaction of epicocconone with human serum albumin is significantly different from its interaction with surfactant assemblies. This observation, along with steady-state fluorescence data, indicates ground-state interaction between the fluorophore epicocconone and the protein. Similarity in fluorescence properties with the adduct of the fluorophore with n-butylamine indicates that bonding occurs at the N-terminus of the protein. |
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| Keywords: | Covalent binding epicocconone synchronous fluorescence spectra fluorescence lifetimes |
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