| 鸟枪法蛋白质组学的研究动态与应用 |
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| 引用本文： | 庞小刚,赵彦修.鸟枪法蛋白质组学的研究动态与应用[J].阜阳师范学院学报(自然科学版),2005,22(4):41-45. |
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| 作者姓名： | 庞小刚 赵彦修 |
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| 作者单位： | 山东师范大学,逆境植物重点实验室,济南,050014 |
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| 摘 要： | 介绍了鸟枪法蛋白质组的系统组成,研究进展以及在医药领域的应用情况．鸟枪法蛋白质组学自出现以来 已经成为研究复杂蛋白质混合物的有力工具．随着色谱和质谱技术的提高,样品制备方法的改进以及多向色谱和蛋 白质组信息学的不断发展,鸟枪法蛋白质组学也遇到了机遇和挑战．
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| 关 键 词： | 鸟枪法 蛋白质组学 研究进展 应用 |
| 文章编号： | 1004-4329（2005）04-0041-05 |
| 收稿时间： | 2005-09-10 |
| 修稿时间： | 2005年9月10日 |
Development and Application of Shotgun Proteomics |
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| PANG Xiao-gang,ZHAO Yan-xiu.Development and Application of Shotgun Proteomics[J].Journal of Fuyang Teachers College:Natural Science,2005,22(4):41-45. |
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| Authors: | PANG Xiao-gang ZHAO Yan-xiu |
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| Institution: | Biology Department of Shandong Normal University, dinan 050014, China |
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| Abstract: | This review introduces the components of this proteomics strategy and describes selected recent applications and emerging innovations in the evolution of shotgun proteomics. Shotgun proteomics has emerged as a powerful approach for the analysis of complex protein mixtures, including biofluids, tissues, cells, organelles or protein complexes. Having evolved from the integration of chromatography and mass spectrometry, innovations in sample preparation, multidimensional chroT matography, mass spectrometry and proteomic informatics continually facilitate, enable and challenge shotgun proteomics. As a result, shotgun proteomics continues to evolve and enable new areas of biological research, and is beginning to impact human disease diagnosis and therapeutic intervention. |
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| Keywords: | shotgun proteomics research innovation recent applications |
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