Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth |
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Authors: | Yan Cai Jie Wu Shi-xiong Xu Quan Long Wei Yao |
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Affiliation: | (1) Anatomisches Institut, Universität Kiel, Olshausenstrasse 40, 24098 Kiel, Germany;(2) Klinik für Neurochirurgie, Universität Kiel, 24098 Kiel, Germany |
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Abstract: | To investigate the inhibiting effects of the anti-angiogenic factor andostatin and the anti-angiogenic drug endostatin on tumour angiogenesis and tumour cells, a coupled mathematical model of tumor angiogenesis with tumour growth and blood perfusion is developed. Simulation results show that angiostatin and endostatin can improve the abnormal microenvironment inside the tumour tissue by effectively inhibiting the process of tumor angiogenesis and decreasing tumour cells. The present model can be used as a valid theoretical method in the investigation of the tumour anti-angiogenic therapy. |
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Keywords: | tumour angiogenesis tumour growth anti-angiogenic therapy coupled mathematical model |
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