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Total synthesis of (−)-baconipyrone C |
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| Authors: | J.S. Yadav K. Sathaiah R. Srinivas |
| Affiliation: | Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A highly stereoselective asymmetric total synthesis of marine polypropionate (−)-baconipyrone C has been achieved. Utilization of desymmetrization technique to create five stereogenic centres, Sharpless epoxidation, Gilman's reaction and resolution of methyl group using enzyme PS-C is the highlight of the synthesis. |
| Keywords: | (&minus )-Baconipyrone C Desymmetrization Enzymatic resolution Sharpless epoxidation Gilmans' reaction |
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