Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin |
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Authors: | Federico Tutino |
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Affiliation: | Department of Chemistry, BU-Oncology, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano (MI), Italy |
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Abstract: | (Z)-Axinohydantoin and (Z)-debromoaxinohydantoin, two pyrrole-imidazole alkaloids isolated from different marine sponges, possess moderate activities in inhibiting the progress of the cell cycle at different phases. A stereoselective synthesis of both natural products was achieved. The key step in the synthetic pathway was the installation of the hydantoin northern ring by using 1-benzoyl-2-methylsulfanyl-1,5-dihydroimidazol-4-one. |
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Keywords: | Alkaloids Natural products Isomerization Kinetics |
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