A general approach to medium-sized ring ethers via hydrolytic and oxidative kinetic resolutions: stereoselective syntheses of (−)-cis-lauthisan and (+)-isolaurepan |
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Authors: | Divya Tripathi |
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Affiliation: | Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India |
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Abstract: | A short and enantioselective approach to medium ring ethers and its application to the syntheses of (−)-cis-lauthisan and (+)-isolaurepan are described. The synthetic strategy features Jacobson's Hydrolytic Kinetic Resolution (HKR), oxidative resolution of secondary alcohol, and highly diastereoselective Et3SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone to give exclusively the different medium-sized cis-disubstituted cyclic ethers. |
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Keywords: | Jacobson's Hydrolytic Kinetic Resolution (HKR) Oxidative resolution of secondary alcohol cis-Reductive cyclization Ring ether Oxepanes |
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