Direct synthesis of primary arylamines via C-N cross-coupling of aryl bromides and triflates with amides |
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Authors: | M Romero |
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Institution: | Laboratori de Química Farmacèutica (Unitat associada al CSIC), Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Spain |
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Abstract: | Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 °C without solvent, and with low catalyst levels (0.12 mol % Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction. |
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Keywords: | Arylamination Coupling Palladium catalyst Primary amines Nucleophilic amides |
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