Replacing the carbonyl's oxygen with the difluoromethyl group |
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| Authors: | Or Cohen |
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| Affiliation: | School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel |
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| Abstract: | Aldehydes or ketones were reacted with 2-(trimethylsilyl)-1,3-dithiane (1) and the products reduced to the corresponding dithianes using tetrafluoroboric acid and sodium borohydride. These sulfur containing compounds were reacted with bromine trifluoride under mild conditions (1-2 min, 0 °C) with a net result of replacing the carbonyls' oxygen with the desired difluoromethyl moiety. |
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