On the Synthesis of 2-Acetyl-4-aryl-6H-1,3,4-thiadiazin-5-ones by Reaction of Nitrilimines with α-Mercapto Alkanoic Acids |
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| Authors: | Bassam A Thaher Hans-Hartwig Otto |
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| Institution: | (1) Chemistry Department, Islamic University, Gaza, Palestine, IL;(2) Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, D-17487 Greifswald, Germany, DE |
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| Abstract: | Summary. N′-Arylacetonitrilimines were generated from acetohydrazonyl chlorides and reacted with mercaptoalkanoic acids forming 4-aryl-5-oxo-3-thiahexanoic
acids. These were cyclized by reaction with dicyclohexyl carbodiimide yielding 2-acetyl-4-aryl-6H-1,3,4-thiadiazin-5-ones.
Received November 13, 2001. Accepted January 9, 2002 |
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| Keywords: | , ,Arylacetonitrilimines, 1,3,4-Thiadiazin-5-ones, Cyclization, |
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