4-hydroxy-2-quinolones 151. Reaction of 4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with p-toluenesulfonylhydrazide期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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4-hydroxy-2-quinolones 151. Reaction of 4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with p-toluenesulfonylhydrazide

Authors:	I V Ukrainets A A Tkach V V Kravtsova A V Turov

Institution:	(1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) Taras Shevchenko Kiev National University, Kiev, 01033, Ukraine

Abstract:	The reaction of ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate with p-toluene-sulfonylhydrazide at room temperature in the system DMSO/K₂CO₃ gives 5-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-5H-pyrazolo4,3-c]quinoline-3,4-dione, alkylation of which using ethyl iodide gives the 1N-substituted derivative. For Communication 150 see 1]. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 59-66, January, 2009.

Keywords:	1 5-dihydropyrazolo[4 3-c]quinolin-4-ones 4-chloro-2-oxo-1 2-dihydroquinoline-3-carboxylates p-toluenesulfonylhydrazide alkylation X-ray structural analysis
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