|
|||||
|
|
Neighborhood search approaches to non-coplanar beam orientation optimization for total marrow irradiation using IMRT |
|
| Authors: | VV Mišić DM Aleman MB Sharpe |
| Institution: | 1. Department of Mechanical and Industrial Engineering, University of Toronto, 5 King’s College Road, Toronto, Canada, ON M5S 3G8;2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 610 University of Avenue, Toronto, Canada, ON M5G 2M9 |
| Abstract: | We consider the beam orientation optimization (BOO) problem for total marrow irradiation (TMI) treatment planning using intensity modulated radiation therapy (IMRT). Currently, IMRT is not widely used in TMI treatment delivery; furthermore, the effect of using non-coplanar beam orientations is not known. We propose and implement several variations of a single neighborhood search algorithm that solves the BOO problem effectively when gantry angles and couch translations are considered. Our work shows that the BOO problem for TMI cases can be solved in a clinically acceptable amount of time and leads to treatment plans that are more effective than the conventional approach to TMI. |
| Keywords: | Total marrow irradiation Total body irradiation Intensity modulated radiation therapy Radiotherapy optimization Local search Beam orientation optimization |
| 本文献已被 ScienceDirect 等数据库收录！ | |