Microwave-enhanced solid-phase synthesis of N,N'-linked aliphatic oligoureas and related hybrids |
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Authors: | Douat-Casassus Céline Pulka Karolina Claudon Paul Guichard Gilles |
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Affiliation: | Université de Bordeaux -CNRS UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac Cedex, France. |
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Abstract: | A practical and efficient microwave-assisted solid-phase method for the synthesis of N,N'-linked oligoureas and related amide/urea hybrid oligomers, featuring the use of succinimidyl (2-azido-2-substituted ethyl) carbamate monomers, is reported. The rate enhancement of urea formation under microwave irradiation combined with the mild conditions of the phosphine-based azide reduction makes this approach very effective for routine synthesis of oligoureas and possibly for library production. |
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