Immunoactivity of polymer microspheres with their hydrophilic/hydrophobic heterogeneous surface sensitized with an antibody |
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Authors: | M. Okubo Y. Yamamoto M. Uno S. Kamei T. Matsumoto |
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Affiliation: | (1) Present address: Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Japan |
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Abstract: | Styrene/2-hydroxyethyl methacrylate polymer microspheres consisting of various polymer compositions were produced by emulsifier-free seeded emulsion polymerization technique. Using these microspheres, which should have hydrophilic/hydrophobic heterogeneous surface, the effects of surface hydrophilicity on the main, fundamental requirements for an immunomicrosphere — high colloidal stability, sensitive immunologic agglutinability and insensitive non-specific agglutinability — were studied in detail. There was a region of the surface hydrophilicity that satisfied the three requirements simultaneously.Part CII of the series Studies on Suspension and Emulsion. |
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Keywords: | Polymer emulsion hydrophilicity heterogeneousstructure immunomicrosphere agglutinability |
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